New Data From Head-to-head Phase 3 Trial Demonstrate That Liraglutide Is More Effective Than Exenatide In Treatment Of Type 2 Diabetes

"In this be taught money off bordered by glycaemia be greater beside liraglutide than with exenatide," said Lawrence Blonde, MD, superintendent of the Ochsner Diabetes Clinical Research Unit in the Department of Endocrinology, Diabetes, and Metabolism at the Oxford Center in New Orleans. "Patients pleasure with once-daily liraglutide achieve finer blood glucose police and also own smaller figure secondary hypoglycaemia than those treated with exenatide." Fasting plasma glucose was also reduced by far more with liraglutide equate to exenatide. Furthermore, liraglutide was also associated with better HOMA-B values, an appraisal of beta-cell manoeuvre.1 The 26-week study integrated 464 inhabitants with genus 2 diabetes who be randomised to psychotherapy with any liraglutide 1.8 mg once each day or exenatide 10 µg twofold daily, both in place of an enhancement to their ongoing treatment consisting of metformin and/or a sulphonylurea.

The overall rate of hypoglycaemia in the study was dwindling. Liraglutide patients tested significantly less minor hypoglycaemia compared to those by exenatide.

Nausea was the peak rife on the side effect in desire of both GLP-1 agonist treatment and was word at a station of 25.5% in the liraglutide sect and 28% in the exenatide group (percent of all study participant television journalism nausea at most minuscule once). In the liraglutide group, the percentage of patients reporting nausea in respectively week fell to 8% after 5 weeks, 4% after 10 weeks and 3% after 26 weeks. In the exenatide group, reports of nausea fell to 13% after 8-10 weeks of treatment and remain above 10% for elapsed 20 weeks.

Other common gastrointestinal-related adverse torment with liraglutide were diarrhoea, vomiting and in doubt belly.

Patients on both treatments mislaid solidity during the study. Weight reduction in patients on liraglutide was also composedly see in the LEADâ„¢ 3a study.2,3,4,5,6 About liraglutide Once-daily liraglutide be the opening human glucagon-like peptide-1 (GLP-1) analogue mechanized for the treatment of type 2 diabetes. Liraglutide works by revitalizing the emanation of insulin and inhibit the release of glucagon from the liver after dinnertime single if blood sugar level be elevated. Weight damage with liraglutide is attributed to the reality that it slow gastric empty and lead to increased satiety after meals.

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